CD28和细胞毒性T淋巴细胞抗原4（CTLA-4）在调节性T细胞生物学中的作用。

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.

作者信息

Sansom David M, Walker Lucy S K

机构信息

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

出版信息

Immunol Rev. 2006 Aug;212:131-48. doi: 10.1111/j.0105-2896.2006.00419.x.

DOI:10.1111/j.0105-2896.2006.00419.x

PMID:16903911

Abstract

The profound influence of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on T-cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell-intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA-4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology.

摘要

CD28和细胞毒性T淋巴细胞抗原4（CTLA-4）对T细胞免疫的深远影响已为人所知超过十年，但这些分子所起的确切作用仍在不断显现。最初被视为提供细胞内共刺激和抑制信号的分子，最近的证据表明，CD28和CTLA-4在一群称为调节性T细胞（Tregs）的抑制性细胞的稳态和功能中也很重要。在这里，我们回顾CD28和CTLA-4系统的主要特征，并研究它们如何影响Treg生物学。