Sabe Hisataka, Onodera Yasuhito, Mazaki Yuichi, Hashimoto Shigeru
Department of Molecular Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.
Curr Opin Cell Biol. 2006 Oct;18(5):558-64. doi: 10.1016/j.ceb.2006.08.002. Epub 2006 Aug 9.
The identification of several ArfGAP proteins as binding partners of paxillin, an integrin signaling and scaffolding protein, has suggested the existence of molecular links between integrin functions and intracellular traffic, as proposed by MS Bretscher long ago. Among the paxillin-binding ArfGAPs, AMAP1 has recently been strongly implicated in tumor invasion as well as malignancy, owing to its highly augmented expression in tumors and its direct involvement in invasive activities. Another ArfGAP, Git2, was found to be a component of the Gbetagamma-mediated directional sensing machinery, while simultaneously playing an essential role in the suppressive control of superoxide production, which is mediated by vesicle transport in GPCR-stimulated neutrophils. These emerging molecular mechanisms may further delineate key processes regulating intracellular traffic as principal controls of cell motility and invasive activities.
几种ArfGAP蛋白被鉴定为桩蛋白（一种整合素信号传导和支架蛋白）的结合伴侣，这表明整合素功能与细胞内运输之间存在分子联系，正如MS Bretscher很久以前所提出的那样。在与桩蛋白结合的ArfGAP中，AMAP1最近因其在肿瘤中的高表达以及直接参与侵袭活动而被强烈认为与肿瘤侵袭和恶性肿瘤有关。另一种ArfGAP，Git2，被发现是Gβγ介导的方向传感机制的一个组成部分，同时在由GPCR刺激的中性粒细胞中的囊泡运输介导的超氧化物产生的抑制控制中起重要作用。这些新出现的分子机制可能会进一步描绘出调节细胞内运输的关键过程，而细胞内运输是细胞运动和侵袭活动的主要控制因素。
