Holzhäuer-Oitzl M S, Hasenöhrl R, Huston J P
Institute of Physiological Psychology, University of Düsseldorf, F.R.G.
Neuropharmacology. 1988 Jul;27(7):749-56. doi: 10.1016/0028-3908(88)90085-8.
The conditioned place preference paradigm was used to assess the reinforcing properties of substance P, injected unilaterally into the region of the nucleus basalis magnocellularis of rats. Over three baseline trials the rats spent more time in either the black (in most cases) or white compartment of the test box (i.e. preferred one compartment). On Day 4 the animals were injected with substance P (1 ng, 100 ng) or vehicle (0.5 microliter) and placed into their non-preferred compartment for 10 min. On Day 5 the positive reinforcing effect of 1 ng substance P was reflected by an increase in the amount of time spent in the compartment in which substance P was administered, as well as by a reversal of the place preference shown during baseline trials. Thus, the injection of substance P into the region of the nucleus basalis may have reinforcing properties in addition to its memory promoting effects that were reported previously.
条件性位置偏爱范式被用于评估单侧注射到大鼠大细胞基底核区域的P物质的强化特性。在三次基线试验中，大鼠在测试箱的黑色（大多数情况下）或白色隔室中花费了更多时间（即偏爱一个隔室）。在第4天，给动物注射P物质（1纳克、100纳克）或赋形剂（0.5微升），并将它们放入非偏爱隔室10分钟。在第5天，1纳克P物质的阳性强化作用表现为在给予P物质的隔室中停留时间增加，以及基线试验期间所表现出的位置偏爱发生反转。因此，向基底核区域注射P物质除了具有先前报道的促进记忆的作用外，可能还具有强化特性。
