Holzhäuer-Oitzl M S, Boucke K, Huston J P
Institute of Physiological Psychology, University of Düsseldorf, F.R.G.
Pharmacol Biochem Behav. 1987 Dec;28(4):511-5. doi: 10.1016/0091-3057(87)90514-4.
Reinforcing properties of substance P (SP) were investigated in rats using a conditioned place preference paradigm. After three baseline trials one conditioning trial of 10 min duration was performed. Either SP (100 pg, 1 ng, 100 ng) or saline (SI) was injected unilaterally into the lateral hypothalamus or a sham injection (OC) was given. Pairing one compartment with SP (100 pg, 1 ng) significantly increased the time spent in this compartment. Microinjections of 100 ng SP, saline or sham injection had no effect. Locomotor activity was not influenced by either treatment. These data are discussed in terms of (a) the possibility that SP has a role in mediating reinforcement and (b) the relationship between reinforcing effects and post-trial effects on learning and memory of SP applied into the lateral hypothalamus.
采用条件性位置偏爱范式在大鼠中研究了P物质（SP）的强化特性。经过三次基线试验后，进行了一次持续10分钟的条件试验。将SP（100皮克、1纳克、100纳克）或生理盐水（SI）单侧注射到下丘脑外侧，或进行假注射（OC）。将一个隔室与SP（100皮克、1纳克）配对显著增加了在该隔室中停留的时间。注射100纳克SP、生理盐水或假注射均无影响。两种处理均未影响运动活动。根据（a）SP在介导强化中发挥作用的可能性以及（b）注入下丘脑外侧的SP的强化效应与试验后对学习和记忆的效应之间的关系对这些数据进行了讨论。
