Edvinsson L
Department of Internal Medicine, Lund University Hospital, Lund S-221 85, Sweden.
Curr Pain Headache Rep. 2001 Feb;5(1):71-8. doi: 10.1007/s11916-001-0013-2.
The cerebral circulation is innervated by sympathetic, parasympathetic, and sensory nerves, which store a considerable number of neurotransmitters. The role of these has been evaluated in primary headaches. A clear association between head pain and the release of calcitonin gene-related peptide was demonstrated. In cluster headache and in a case of chronic paroxysmal headache there was in addition the release of vasoactive intestinal peptide, which was associated with the facial symptoms (nasal congestion, rhinorrhea). In parallel with sumatriptan treatment, head pain subsided and neuropeptide release normalized. These data show the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headaches.
脑循环由交感神经、副交感神经和感觉神经支配，这些神经储存着大量神经递质。其在原发性头痛中的作用已得到评估。已证实头痛与降钙素基因相关肽的释放之间存在明确关联。在丛集性头痛和一例慢性阵发性头痛中，还释放了血管活性肠肽，这与面部症状（鼻塞、流涕）有关。与舒马曲坦治疗同时，头痛缓解，神经肽释放恢复正常。这些数据表明感觉和副交感神经机制参与了原发性头痛的病理生理学过程。
