Maruoka Hiroshi, Honda Seiyo, Takeo Masaaki, Koga Takeharu, Fukuda Takaaki, Aizawa Hisamichi
Department of Medicine, Division of Respiratology and Neurology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan.
Mod Rheumatol. 2006;16(4):264-6. doi: 10.1007/s10165-006-0494-2.
A 23-year-old woman presented with recurrence of lupus cystitis, which had been in remission under daily administration of a single corticosteroid over a period of 8 years. She was treated with increased doses of corticosteroid and immunosuppressants, i.e., cyclosporin, cyclophosphamide, azathioprine, and salazosulfapyridine, but the cystitis remained active. Since her condition became critical by the complication of intestinal pseudo-obstruction, tacrolimus was administered. This agent induced a remission promptly without significant adverse events in this patient, suggesting an efficacy to lupus cystitis refractory to corticosteroid and other immunosuppressants.
一名23岁女性出现狼疮性膀胱炎复发，该病在每日服用单一皮质类固醇的情况下已缓解8年。她接受了增加剂量的皮质类固醇和免疫抑制剂治疗，即环孢素、环磷酰胺、硫唑嘌呤和柳氮磺胺吡啶，但膀胱炎仍处于活动期。由于她因肠道假性梗阻并发症病情危急，于是给予了他克莫司治疗。该药物迅速诱导缓解，且该患者未出现明显不良事件，提示其对皮质类固醇和其他免疫抑制剂难治的狼疮性膀胱炎有效。
