Coyne Karin S, Tubaro Andrea, Brubaker Linda, Bavendam Tamara
Center for Health Outcomes Research, United BioSource Corporation, Bethesda, Maryland 20814, USA.
Urology. 2006 Aug;68(2 Suppl):9-16. doi: 10.1016/j.urology.2006.05.042.
Patient-reported outcome (PRO) measures are a valuable means for determining how a disease and its treatment affect patients, including effects on health-related quality of life (HRQL). To ensure that the results obtained with PROs are clinically useful, data must be gathered using valid and reliable instruments. Developing such instruments requires a multistep, structured process that incorporates cognitive psychology, psychometric theory, and patient and clinician input. The process begins by determining the intent and purpose of the PRO and culminates in studies that demonstrate the measure's validity, reliability, and responsiveness. Several valid and reliable PROs are available for assessing the effects of treatment on symptom severity, symptom bother, and HRQL in patients with overactive bladder.
患者报告结局（PRO）测量是确定疾病及其治疗如何影响患者的一种有价值的手段，包括对健康相关生活质量（HRQL）的影响。为确保使用PRO获得的结果具有临床实用性，必须使用有效且可靠的工具收集数据。开发此类工具需要一个多步骤的结构化过程，该过程纳入认知心理学、心理测量理论以及患者和临床医生的意见。该过程始于确定PRO的意图和目的，并最终进行研究以证明该测量方法的有效性、可靠性和反应性。有几种有效且可靠的PRO可用于评估治疗对膀胱过度活动症患者症状严重程度、症状困扰和HRQL的影响。
