Broome Bede M, Jayaraman Vivek, Laurent Gilles
Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, 91125, USA.
Neuron. 2006 Aug 17;51(4):467-82. doi: 10.1016/j.neuron.2006.07.018.
Odors evoke complex responses in locust antennal lobe projection neurons (PNs)-the mitral cell analogs. These patterns evolve over hundreds of milliseconds and contain information about odor identity and concentration. In nature, animals often encounter many odorants in short temporal succession. We explored the effects of such conditions by presenting two different odors with variable intervening delays. PN ensemble representations tracked stimulus changes and, in some delay conditions, reached states that corresponded neither to the representation of either odor alone nor to the static mixture of the two. We then recorded from Kenyon cells (KCs), the PNs' targets. Their responses were consistent with the PN population's behavior: in some conditions, KCs were recruited that did not fire during single-odor or mixture stimuli. Thus, PN population dynamics are history dependent, and responses of individual KCs are consistent with piecewise temporal decoding of PN output over large sections of the PN population.
气味会引发蝗虫触角叶投射神经元（PNs，即类似双极细胞的神经元）的复杂反应。这些反应模式在数百毫秒内不断演变，包含有关气味特性和浓度的信息。在自然环境中，动物常常在短时间内接连遇到多种气味。我们通过呈现两种不同气味并设置可变的间隔延迟来探究这种情况的影响。PN集合表征追踪刺激变化，并且在某些延迟条件下，会达到既不对应于单独一种气味的表征，也不对应于两种气味静态混合表征的状态。然后，我们记录了PNs的靶标——肯扬细胞（KCs）的活动。它们的反应与PN群体的行为一致：在某些条件下，会募集到在单种气味或混合刺激时不放电的KCs。因此，PN群体动态是依赖于历史的，并且单个KC的反应与在PN群体大部分区域上对PN输出进行的分段时间解码一致。
