Rafal Robert D
Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, University of Wales, Bangor, UK.
Cortex. 2006 Jul;42(5):730-9. doi: 10.1016/s0010-9452(08)70411-8.
This review summarises research in patients with chronic lesions of parietal oculomotor cortex and compares their oculomotor performance to patients with lesions of the frontal eye field (FEF). The observations identify the oculomotor functions for which these regions are indispensable, and explore dynamic interactions within cortical and subcortical networks for oculomotor control. The experiments examined endogenously generated saccades, saccades to visual targets, antisaccades, saccade choice and saccade remapping for inhibitory spatial tagging. The findings suggest that the key function of parietal oculomotor cortex is the computation of sensorimotor transformations, rather than the initiation of either voluntary or reflexive saccades. They also reveal the re-organisation of cortico-subcortical networks after brain injury, and provide insight into their dynamic interactions: FEF lesions result in disinhibition of reflexive saccades toward the contralesional field and an impairment of reflexive saccades toward the ipsilesional field; whereas parietal lesion result in the opposite pattern.
本综述总结了对顶叶动眼皮质慢性损伤患者的研究，并将他们的动眼表现与额叶眼区（FEF）损伤患者进行比较。这些观察确定了这些区域不可或缺的动眼功能，并探索了动眼控制的皮质和皮质下网络内的动态相互作用。实验研究了内源性产生的扫视、对视觉目标的扫视、反扫视、扫视选择以及用于抑制性空间标记的扫视重映射。研究结果表明，顶叶动眼皮质的关键功能是感觉运动转换的计算，而不是自主或反射性扫视的启动。它们还揭示了脑损伤后皮质-皮质下网络的重组，并深入了解了它们的动态相互作用：FEF损伤导致对侧视野的反射性扫视去抑制和同侧视野的反射性扫视受损；而顶叶损伤则导致相反的模式。
