Gräter H
Klinik für Onkologie, Gastroenterologie und Allgemeine Innere Medizin, Städtische Kliniken Esslingen.
Praxis (Bern 1994). 2006 Aug 2;95(31-32):1179-83. doi: 10.1024/0369-8394.95.31.1179.
Proton pump inhibitors (PPI) are the antisecretory drugs of choice to manage GERD-related problems. The therapeutic goal in patients with non erosive reflux disease (NERD) and low-grade-GERD is to relieve symptoms, therefore PPI are given "on demand". Severe GERD requires long term treatment to heal lesions and to prevent relapses and complications. Barrett's esophagus has to be regarded as a precancerous lesion, therefore surveillance strategy is required. Functional dyspepsia is a common reason for upper gastrointestinal symptoms. If there are no alarming symptoms, you can omit endoscopy in younger patients. The treatment is empirical and symptom driven. Psychologic therapy is a promising avenue in some patients.
质子泵抑制剂（PPI）是治疗胃食管反流病相关问题的首选抗分泌药物。非糜烂性反流病（NERD）和轻度胃食管反流病患者的治疗目标是缓解症状，因此PPI采用“按需给药”。重度胃食管反流病需要长期治疗以愈合病变、预防复发和并发症。巴雷特食管必须被视为癌前病变，因此需要进行监测。功能性消化不良是上消化道症状的常见原因。如果没有警示症状，年轻患者可省略内镜检查。治疗是经验性的且以症状为导向。心理治疗对一些患者来说是一条有前景的途径。
