克里米亚-刚果出血热病毒基因组学与全球多样性
Crimean-Congo hemorrhagic fever virus genomics and global diversity.
作者信息
Deyde Varough M, Khristova Marina L, Rollin Pierre E, Ksiazek Thomas G, Nichol Stuart T
机构信息
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Atlanta, GA 30329, USA.
出版信息
J Virol. 2006 Sep;80(17):8834-42. doi: 10.1128/JVI.00752-06.
Abstract
Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that occurs in Africa, Europe, the Middle East, and Asia. The complete genomes of 13 geographically and temporally diverse virus strains were determined, and CCHF viruses were found to be highly variable with 20 and 8%, 31 and 27%, and 22 and 10% nucleotide and deduced amino acid differences detected among virus S (nucleocapsid), M (glycoprotein), and L (polymerase) genome segments, respectively. Distinct geographic lineages exist, but with multiple exceptions indicative of long-distance virus movement. Discrepancies among the virus S, M, and L phylogenetic tree topologies document multiple RNA segment reassortment events. An analysis of individual segment datasets suggests genetic recombination also occurs. For an arthropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high.
摘要
克里米亚-刚果出血热（CCHF）是一种病死率很高的严重疾病，在非洲、欧洲、中东和亚洲均有发生。测定了13株在地理和时间上具有多样性的病毒株的完整基因组，发现CCHF病毒具有高度变异性，在病毒S（核衣壳）、M（糖蛋白）和L（聚合酶）基因组片段中分别检测到20%和8%、31%和27%以及22%和10%的核苷酸差异和推导氨基酸差异。存在不同的地理谱系，但有多个例外表明病毒存在远距离传播。病毒S、M和L系统发育树拓扑结构之间的差异记录了多个RNA片段重配事件。对单个片段数据集的分析表明也发生了基因重组。对于一种虫媒病毒而言，CCHF病毒的基因组可塑性出奇地高。
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