De Castro Stefano, Caselli Stefano, Maron Martin, Pelliccia Antonio, Cavarretta Elena, Maddukuri Prasad, Cartoni Domenico, Di Angelantonio Emanuele, Kuvin Jeffrey T, Patel Ayan R, Pandian Natesa G
Department of Cardiovascular, Respiratory and Morphological Sciences, La Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Heart. 2007 Feb;93(2):205-9. doi: 10.1136/hrt.2006.093997. Epub 2006 Aug 16.
Various studies have reported a close correlation between real-time three-dimensional echocardiography (RT3DE) and cine magnetic resonance imaging studies for the assessment of cardiac volumes and mass.
The aim of our study was to evaluate changes in left ventricular volumes and mass in subjects with different pathophysiological conditions. A ratio between left ventricular mass and end-diastolic volume (LVRI), detected by RT3DE, was used to describe various patterns of left ventricular remodelling.
RT3DE was performed to calculate left ventricular end-diastolic (LVEDV) and end-systolic volume (LVESV), ejection fraction (LVEF) and mass in 220 selected subjects. Of these, 152 were healthy volunteers, 19 top-level rowers, 23 patients with dilated cardiomyopathy and 26 patients with hypertrophic cardiomyopathy. Off-line analysis was performed by two independent operators by tracing manual endocardial and epicardial borders of the left ventricle through eight cutting planes. Inter- and intra-observer variability were calculated.
Despite the increase in LV volume and mass in the rowers, LVRI remained unchanged compared with control subjects (p = 0.455), while significantly lower values were found patients with dilated cardiomyopathy (p<0.001) and significantly higher values in patients with hypertrophic cardiomyopathy (p<0.001). There was inter- and intra-observer variability.
The LVRI may serve as a simple and useful indicator of left ventricular adaptation to physiological and pathological conditions.
多项研究报告了实时三维超声心动图（RT3DE）与电影磁共振成像研究在评估心脏容积和质量方面的密切相关性。
我们研究的目的是评估不同病理生理状况受试者左心室容积和质量的变化。通过RT3DE检测的左心室质量与舒张末期容积之比（LVRI）用于描述左心室重构的各种模式。
对220名选定受试者进行RT3DE检查，以计算左心室舒张末期容积（LVEDV）、收缩末期容积（LVESV）、射血分数（LVEF）和质量。其中，152名是健康志愿者，19名顶级赛艇运动员，23名扩张型心肌病患者和26名肥厚型心肌病患者。由两名独立操作人员通过八个切面手动追踪左心室的心内膜和心外膜边界进行离线分析。计算观察者间和观察者内的变异性。
尽管赛艇运动员的左心室容积和质量增加，但与对照组相比，LVRI保持不变（p = 0.455），而扩张型心肌病患者的值显著较低（p<0.001），肥厚型心肌病患者的值显著较高（p<0.001）。存在观察者间和观察者内的变异性。
LVRI可能是左心室适应生理和病理状况的一个简单而有用的指标。
