树突状细胞与肿瘤微环境：危险的关联
Dendritic cells and tumor microenvironment: a dangerous liaison.
作者信息
Fricke Ingo, Gabrilovich Dmitry I
机构信息
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA.
出版信息
Immunol Invest. 2006;35(3-4):459-83. doi: 10.1080/08820130600803429.
Abstract
The fact that the immune response to cancer is compromised has been convincingly demonstrated in murine tumor models as well as in cancer patients. The unresponsiveness of the host immune system is one of the major mechanisms of tumor escape as well as an important factor that limits the success of cancer immunotherapy. Inadequate function of professional antigen presenting cells dendritic cells (DC) in cancer is one of the major elements of compromised anti-tumor immune response. Despite substantial progress in recent years, the mechanism of inadequate DC function in cancer still remains unclear. The tumor microenvironment has emerged as an important component contributing to DC malfunction. In this review we will discuss the potential role of tumor microenvironment in DC dysfunction.
摘要
在小鼠肿瘤模型以及癌症患者中，对癌症的免疫反应受损这一事实已得到令人信服的证明。宿主免疫系统的无反应性是肿瘤逃逸的主要机制之一，也是限制癌症免疫治疗成功的一个重要因素。癌症中专业抗原呈递细胞树突状细胞（DC）功能不足是抗肿瘤免疫反应受损的主要因素之一。尽管近年来取得了重大进展，但癌症中DC功能不足的机制仍不清楚。肿瘤微环境已成为导致DC功能障碍的一个重要因素。在本综述中，我们将讨论肿瘤微环境在DC功能障碍中的潜在作用。
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