MRC Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.
Int J Mol Sci. 2024 Jun 7;25(12):6302. doi: 10.3390/ijms25126302.
Mitochondrial one-carbon metabolism provides carbon units to several pathways, including nucleic acid synthesis, mitochondrial metabolism, amino acid metabolism, and methylation reactions. Late-onset Alzheimer's disease is the most common age-related neurodegenerative disease, characterised by impaired energy metabolism, and is potentially linked to mitochondrial bioenergetics. Here, we discuss the intersection between the molecular pathways linked to both mitochondrial one-carbon metabolism and Alzheimer's disease. We propose that enhancing one-carbon metabolism could promote the metabolic processes that help brain cells cope with Alzheimer's disease-related injuries. We also highlight potential therapeutic avenues to leverage one-carbon metabolism to delay Alzheimer's disease pathology.
线粒体一碳代谢为包括核酸合成、线粒体代谢、氨基酸代谢和甲基化反应在内的多个途径提供碳单位。迟发性阿尔茨海默病是最常见的与年龄相关的神经退行性疾病，其特征是能量代谢受损，并且可能与线粒体生物能学有关。在这里，我们讨论了与线粒体一碳代谢和阿尔茨海默病相关的分子途径之间的交叉点。我们提出，增强一碳代谢可以促进帮助脑细胞应对与阿尔茨海默病相关损伤的代谢过程。我们还强调了利用一碳代谢来延缓阿尔茨海默病病理的潜在治疗途径。
