从柘树中分离得到的儿茶酚氧杂蒽酮和黄酮类化合物的抗动脉粥样硬化及抗炎活性
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
作者信息
Park Ki Hun, Park Yong-Dae, Han Jong-Min, Im Kyung-Ran, Lee Byong Won, Jeong Il Yun, Jeong Tae-Sook, Lee Woo Song
机构信息
National Research Laboratory of Lipid Metabolism and Atherosclerosis, Insect Resources Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 3806, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. doi: 10.1016/j.bmcl.2006.08.032. Epub 2006 Aug 21.
The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.
从柘树的根皮中分离出了儿茶酚型氧杂蒽酮和黄酮类化合物1-13。在硫代巴比妥酸反应性物质（TBARS）测定中，化合物1和3-8对低密度脂蛋白（LDL）氧化表现出显著的抗氧化活性。其中，异戊烯基化黄酮类化合物10-12对RAW264.7细胞中NO的产生和iNOS的表达具有抑制作用。此外，化合物1、2、5、7、9和11对hACAT-2的抑制作用优于hACAT-1，而化合物3、4、6和8对hACAT-1和-2表现出相似的特异性。然而，黄酮类化合物10、12和13主要抑制hACAT-2，而非hACAT-1。
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