Parsons W D, Pelletier J G
Can Med Assoc J. 1982 Sep 1;127(5):377-80.
Caffeine elimination was studied in 15 women at 38 to 40 weeks' gestation. The mean hourly caffeine clearance, 37 ml/kg, determined from assays of saliva, was only 39% of the value previously reported for nonpregnant adults (94 ml/kg). Reassessment in four of the women 2 to 12 weeks post partum showed that in each woman the caffeine clearance had increased more than threefold and that the mean caffeine concentration in the saliva after no intake of caffeine for 24 hours was now much lower (0.07 v. 0.84 microgram/ml).
对15名妊娠38至40周的女性进行了咖啡因清除研究。通过唾液检测确定的平均每小时咖啡因清除率为37毫升/千克，仅为先前报道的非孕成年女性（94毫升/千克）数值的39%。对其中4名女性在产后2至12周进行重新评估，结果显示每位女性的咖啡因清除率增加了三倍多，并且在24小时未摄入咖啡因后，唾液中的平均咖啡因浓度现在低得多（0.07微克/毫升对0.84微克/毫升）。
