GenePro：一款用于高级可视化和分析相互作用网络的Cytoscape插件。
GenePro: a Cytoscape plug-in for advanced visualization and analysis of interaction networks.
作者信息
Vlasblom James, Wu Samuel, Pu Shuye, Superina Mark, Liu Gina, Orsi Chris, Wodak Shoshana J
机构信息
Structural Biology and Biochemistry Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
出版信息
Bioinformatics. 2006 Sep 1;22(17):2178-9. doi: 10.1093/bioinformatics/btl356.
MOTIVATION
Analyzing the networks of interactions between genes and proteins has become a central theme in systems biology. Versatile software tools for interactively displaying and analyzing these networks are therefore very much in demand. The public-domain open software environment Cytoscape has been developed with the goal of facilitating the design and development of such software tools by the scientific community.
RESULTS
We present GenePro, a plugin to Cytoscape featuring a set of versatile tools that greatly facilitates the visualization and analysis of protein networks derived from high-throughput interactions data and the validation of various methods for parsing these networks into meaningful functional modules.
AVAILABILITY
The GenePro plugin is available at the website http://genepro.ccb.sickkids.ca.
动机
分析基因与蛋白质之间的相互作用网络已成为系统生物学的核心主题。因此，迫切需要用于交互式显示和分析这些网络的通用软件工具。公共领域的开放软件环境Cytoscape的开发目的是促进科学界设计和开发此类软件工具。
结果
我们展示了GenePro，这是Cytoscape的一个插件，具有一组通用工具，极大地促进了从高通量相互作用数据中衍生的蛋白质网络的可视化和分析，以及将这些网络解析为有意义的功能模块的各种方法的验证。
可用性
GenePro插件可在网站http://genepro.ccb.sickkids.ca上获取。
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