Hamburger A E, Bjorkman P J, Herr A B
Division of Biology, California Institute of Technology, 114-96, Pasadena, CA 91125, USA.
Curr Top Microbiol Immunol. 2006;308:173-204. doi: 10.1007/3-540-30657-9_8.
The mucosal regions of the body are responsible for defense against environmental pathogens. Particularly in the lumen of the gut, antibody-mediated immune responses are critical for preventing invasion by pathogens. In this chapter, we review structural studies that have illuminated various aspects of mucosal immunity. Crystal structures of IgA1-Fc and IgA-binding fragments of the polymeric immunoglobulin receptor and Fc alphaRI, combined with models of intact IgA and IgM from solution scattering studies, reveal potential mechanisms for immune exclusion and induction of inflammatory responses. Other recent structures yield insights into bacterial mechanisms for evasion of the host immune response.
身体的黏膜区域负责抵御环境病原体。特别是在肠道腔内，抗体介导的免疫反应对于防止病原体入侵至关重要。在本章中，我们回顾了阐明黏膜免疫各个方面的结构研究。IgA1-Fc以及多聚免疫球蛋白受体和FcαRI的IgA结合片段的晶体结构，结合溶液散射研究中完整IgA和IgM的模型，揭示了免疫排斥和炎症反应诱导的潜在机制。其他近期的结构研究为细菌逃避宿主免疫反应的机制提供了见解。
