Cantor Louis B
Indiana University School of Medicine, USA.
Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):151-7. doi: 10.1517/17425255.1.1.151.
Bimatoprost (Lumigan), Allergan) is a highly efficacious ocular hypotensive agent that provides good diurnal control of intraocular pressure in glaucoma and ocular hypertensive patients. Bimatoprost is a synthetic molecule that is structurally and pharmacologically similar to prostamide F(2), and appears to mimic the activity of the prostamides. Consistent with prostamide-mimetic activity, bimatoprost has potent inherent pharmacological activity in prostamide-sensitive preparations and essentially remains intact in the living primate eye. This is sufficient to explain its potent and efficacious ocular hypotensive activity, and suggests that bimatoprost is a pharmacologically unique compound.
比马前列素（卢美根，艾尔建公司生产）是一种高效的降眼压药物，可有效控制青光眼和高眼压症患者的日间眼压。比马前列素是一种合成分子，其结构和药理作用与前列腺素F(2)类似，似乎能模拟前列腺素的活性。与模拟前列腺素的活性一致，比马前列素在对前列腺素敏感的制剂中具有强大的固有药理活性，并且在灵长类动物的活体眼中基本保持完整。这足以解释其强大而有效的降眼压活性，并表明比马前列素是一种药理特性独特的化合物。
