Kaliaperumal Subashini, Govindaraj Indu, Kopparapu Praveen Kumar, Ahuja Shashi
Department of Ophthalmology, JawaharIal Institute of Postgraduate Medical Education and Research, Puducherry, Tamil Nadu, India.
J Pharmacol Pharmacother. 2014 Jul;5(3):208-10. doi: 10.4103/0976-500X.136110.
Prostaglandin F2 alpha (PGF2α) analogues including bimatoprost are often the first line drugs used in the treatment of glaucoma. We present a case of a 62-year-old female patient who was started on bimatoprost in both the eyes for primary open angle glaucoma. The intraocular pressures reached the target level but she developed hair growth over the chin and upper lip after six months of commencing of the treatment. The regional hypertrichosis did not reduce much after stopping the drug. Hirsutism is a potential side effect of prostaglandin analogues which has rarely been reported. Doctors and patients need to be aware of this noticeable and unwanted side effect. The effect seems to occur in patients already having few non-vellus hairs in these areas.
包括比马前列素在内的前列腺素F2α（PGF2α）类似物通常是治疗青光眼的一线药物。我们报告一例62岁女性患者，因原发性开角型青光眼开始双眼使用比马前列素治疗。眼压达到了目标水平，但在开始治疗6个月后，她的下巴和上唇出现了毛发增多。停药后局部多毛症并没有明显减轻。多毛症是前列腺素类似物的一种潜在副作用，很少有相关报道。医生和患者需要了解这种明显且不良的副作用。这种效应似乎发生在这些部位本来就几乎没有毳毛的患者身上。
