Jung Jae Yoon, Choi Yu Sung, Yoon Mi Young, Min Seong Uk, Suh Dae Hun
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Dermatol Surg. 2009 Aug;35(8):1181-7. doi: 10.1111/j.1524-4725.2008.34427.x. Epub 2009 Jan 21.
The effect of combined 585/1,064-nm (sequential dual-wavelength pulsed dye laser (PDL) and neodymium-doped yttrium aluminium garnet) laser therapy for acne vulgaris has not been evaluated.
To compare the efficacy and safety of PDL and of combined 585/1,064-nm laser treatment for mild to moderate facial acne.
A 12-week, randomized, prospective, split-face, double-blind study was performed. Sixteen participants with mild to moderate acne were treated with a single pass of a combined 585/1,064-nm laser on half of the face and PDL on the other half during each treatment session. Patients underwent three treatment sessions at 2-week intervals and were followed up at 8 and 12 weeks after treatment commencement.
At the final visit, inflammatory acne lesions were reduced by 86% on the PDL sides and by 89% on the 585/1,064-nm laser sides. Noninflammatory acne lesions showed corresponding reductions of 69% and 64%, respectively. A significant difference between the two treatments was observed for noninflammatory acne lesions at the eighth week. Histopathologic examinations showed that both treatments decreased inflammation and interleukin-8 expression and increased transforming growth factor beta expression.
PDL and combined 585/1,064 nm laser were safe and effective for the treatment of inflammatory and noninflammatory acne lesions.
585/1064纳米联合（序贯双波长脉冲染料激光（PDL）和掺钕钇铝石榴石）激光疗法治疗寻常痤疮的效果尚未得到评估。
比较PDL和585/1064纳米联合激光治疗轻至中度面部痤疮的疗效和安全性。
进行了一项为期12周的随机、前瞻性、半脸、双盲研究。16名轻至中度痤疮患者在每次治疗时，一侧面部接受单次585/1064纳米联合激光治疗，另一侧面部接受PDL治疗。患者每隔2周进行3次治疗，并在治疗开始后的第8周和第12周进行随访。
在最后一次随访时，PDL侧的炎性痤疮皮损减少了86%，585/1064纳米激光侧减少了89%。非炎性痤疮皮损分别相应减少了69%和64%。在第8周时，观察到两种治疗方法在非炎性痤疮皮损方面存在显著差异。组织病理学检查表明，两种治疗方法均降低了炎症和白细胞介素-8的表达，并增加了转化生长因子β的表达。
PDL和585/1064纳米联合激光治疗炎性和非炎性痤疮皮损安全有效。
