EUS-guided FNA of proximal biliary strictures after negative ERCP brush cytology results.

BACKGROUND

Accurate nonoperative diagnosis of proximal biliary strictures (PBSs) is often difficult.

OBJECTIVE

To report our experience with EUS-guided FNA (EUS-FNA) of PBSs following negative or unsuccessful results with brush cytology during ERCP.

DESIGN

Retrospective cohort study.

SETTING

Single, tertiary referral hospital in Indianapolis, Indiana.

PATIENTS

Consecutive subjects from January 2001 to November 2004 who underwent EUS-FNA of a PBS documented by ERCP.

INTERVENTIONS

EUS-FNA of PBS.

MAIN OUTCOME MEASURES

Performance of EUS-FNA, with the final diagnosis determined by surgical pathology study or the results of EUS-FNA and follow-up.

RESULTS

A total of 291 biliary strictures undergoing EUS were identified. Of these, 26 (9%) had PBSs and 2 were excluded. EUS-FNA was not attempted in 1 because no mass was visualized. The second had a PBS seen on magnetic resonance cholangiopancreatography, but no ERCP was performed. Twenty-four patients (14 men; mean age, 68 years) underwent EUS-FNA of a PBS following ERCP brush cytology studies that were either negative/nondiagnostic (20) or unable to be performed (4). EUS visualized a mass in 23 (96%) patients, including 13 in whom previous imaging detected no lesion. EUS-FNA (median, 4 passes; range, 1-11) demonstrated malignancy in 17 of 24 (71%) patients with findings showing adenocarcinoma (15), lymphoma (2), atypical cytology (3), or benign cells (4). No complications were noted. Pathology results from 8 of 24 (33%) patients who underwent surgery showed hilar cholangiocarcinoma (6), gallbladder cancer (1), and a benign, inflammatory stricture (1). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EUS-FNA were 77% (95% confidence interval [CI], 54%-92%), 100% (95% CI, 15%-100%), 100% (95% CI, 83%-100%), 29% (95% CI, 4%-71%), and 79% (95% CI, 58%-93%), respectively.

LIMITATIONS

Histopathologic correlation of EUS-FNA findings was limited to 8 of 24 (33%) patients who underwent surgery.

CONCLUSIONS

EUS-FNA is a sensitive method for the diagnosis of PBSs following negative results or unsuccessful ERCP brush cytology. The low negative predictive value does not permit reliable exclusion of malignancy following a negative biopsy.