van Brummelen S E, de Vries E, Schneeberger P M, van Binnendijk R S, Lestrade P, Wever P C
Jeroen Bosch Ziekenhuis, Postbus 90.153, 5200 ME's-Hertogenbosch.
Ned Tijdschr Geneeskd. 2006 Aug 5;150(31):1732-5.
Two patients, men aged 17 and 19 years respectively, were admitted with parotitis epidemica and orchitis caused by mumps. The second patient also had meningitis. PCR analysis revealed that, in both cases, the causative agentwas a mumps virus that was genetically related to a wild-type virus responsible for an outbreak in Singapore. This viral strain was also responsible for a mumps outbreak at Hotel School The Hague in September 2004. Both patients were not fully vaccinated. Both patients were from regions in which clustering of patients with clinical signs of mumps has been seen. Interestingly, a number of patients with confirmed mumps had been fully vaccinated. Possible explanations for the increase in mumps cases include low vaccination and immunity levels, primary and secondary vaccine failure and the emergence of genetically disparate mumps viruses.
两名患者，分别为17岁和19岁男性，因腮腺炎并发流行性腮腺炎和睾丸炎入院。第二名患者还患有脑膜炎。聚合酶链反应（PCR）分析显示，在这两例病例中，病原体均为腮腺炎病毒，其基因与导致新加坡一次疫情爆发的野生型病毒相关。该病毒株还导致了2004年9月海牙酒店管理学院的腮腺炎疫情爆发。两名患者均未完全接种疫苗。两名患者均来自出现腮腺炎临床症状患者聚集的地区。有趣的是，一些确诊为腮腺炎的患者已完全接种疫苗。腮腺炎病例增加的可能原因包括疫苗接种率和免疫力水平低、初次和二次疫苗接种失败以及基因不同的腮腺炎病毒的出现。
