Municipal Health Service "Midden-Nederland", Zeist, The Netherlands.
Vaccine. 2011 Nov 28;29(51):9551-6. doi: 10.1016/j.vaccine.2011.09.100. Epub 2011 Oct 5.
During a recent mumps epidemic in the Netherlands caused by a genotype D mumps virus strain, we investigated the potential of vaccinated people to spread mumps disease to close contacts. We compared mumps viral titers of oral fluid specimens obtained by quantitative PCR from vaccinated (n=60) and unvaccinated (n=111) mumps patients. We also investigated the occurrence of mumps infection among the household contacts of vaccinated mumps patients. We found that viral titers are higher for unvaccinated patients than for vaccinated patients during the 1st 3 days after onset of disease. While no symptomatic cases were reported among the household contacts (n=164) of vaccinated mumps patients (n=36), there were cases with serological evidence of asymptomatic infection among vaccinated household contacts (9 of 66 vaccinated siblings). For two of these siblings, the vaccinated index patient was the most probable source of infection. We conclude that, in this particular outbreak, the risk of a close contact becoming infected by vaccinated patients was small, but present.
在荷兰最近的一次由基因型 D 腮腺炎病毒株引起的腮腺炎流行中，我们研究了接种疫苗的人将腮腺炎疾病传播给密切接触者的潜力。我们比较了定量 PCR 从接种疫苗的（n=60）和未接种疫苗的（n=111）腮腺炎患者的口腔液标本中获得的腮腺炎病毒滴度。我们还调查了接种腮腺炎疫苗患者的家庭接触者中腮腺炎感染的发生情况。我们发现，在疾病发病后的头 3 天，未接种疫苗患者的病毒滴度高于接种疫苗患者。虽然在接种腮腺炎疫苗患者（n=36）的家庭接触者（n=164）中未报告有症状病例，但在接种疫苗的家庭接触者（n=66 名接种疫苗的兄弟姐妹中有 9 人）中出现了无症状感染的血清学证据。对于其中两名兄弟姐妹，接种疫苗的指数患者是最有可能的感染源。我们的结论是，在这种特定的暴发中，密切接触者被接种疫苗的患者感染的风险很小，但确实存在。
