2004 年荷兰高度接种疫苗的学生人群中发生腮腺炎暴发。

Mumps outbreak in a highly vaccinated student population, The Netherlands, 2004.

机构信息

Department Infectious Disease, Municipal Health Service, The Hague, The Netherlands.

出版信息

Vaccine. 2010 Apr 9;28(17):2932-6. doi: 10.1016/j.vaccine.2010.02.020. Epub 2010 Feb 25.

DOI:10.1016/j.vaccine.2010.02.020

PMID:20188683

Abstract

In September 2004 a mumps outbreak occurred at an international hotel school in The Netherlands. We investigated this outbreak to identify risk factors for mumps. There were 105 mumps cases (overall mumps attack rate (AR) 12% (95% CI: 10-15%)). The AR for Dutch vaccinated and unvaccinated participants was 12% (95% CI: 10-15%) and 15% (95% CI: 3-42%), respectively. Independent risk factor was mumps contact. Explanations for the relatively high AR among vaccinated participants include primary vaccine failure, waning immunity and incomplete vaccine-induced immunity in the context of high mumps virus exposure in a school party and a crowded boarding school.

摘要

2004 年 9 月，荷兰一家国际酒店学校发生了腮腺炎暴发。我们对此次暴发进行了调查，以确定腮腺炎的危险因素。共有 105 例腮腺炎病例（总体腮腺炎发病率 (AR) 为 12%（95%CI：10-15%））。荷兰接种疫苗和未接种疫苗的参与者的 AR 分别为 12%（95%CI：10-15%）和 15%（95%CI：3-42%）。腮腺炎接触是独立的危险因素。对于接种疫苗的参与者中相对较高的 AR 的解释包括原发性疫苗失败、免疫衰减以及在学校聚会和拥挤的寄宿学校中高腮腺炎病毒暴露的背景下疫苗诱导的免疫不完全。