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在通过气溶胶感染的豚鼠中，肺淋巴管是结核分枝杆菌感染的主要部位。

Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.

作者信息

Basaraba Randall J, Smith Erin E, Shanley Crystal A, Orme Ian M

机构信息

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1619, USA.

出版信息

Infect Immun. 2006 Sep;74(9):5397-401. doi: 10.1128/IAI.00332-06.

DOI:10.1128/IAI.00332-06
PMID:16926435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1594862/
Abstract

Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

摘要

结核分枝杆菌在经低剂量气溶胶感染的豚鼠肺部引发淋巴管炎。这一观察结果表明，肺淋巴管除了是从肺部到区域淋巴结的直接通道外，其本身也是感染部位，并且可能是潜伏感染的部位。

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本文引用的文献

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Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis.在豚鼠结核病模型中，淋巴结炎是疾病的主要组成部分。
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In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection.体内清除CD11c+细胞会延迟CD4+ T细胞对结核分枝杆菌的反应，并加重感染结果。
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Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.卡介苗皮内接种后，中性粒细胞通过淋巴管迅速迁移，并将活的杆菌输送至引流淋巴结。
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Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.感染结核分枝杆菌的豚鼠肺部病变的磁共振成像
Infect Immun. 2004 Oct;72(10):5963-71. doi: 10.1128/IAI.72.10.5963-5971.2004.
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The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era.儿童胸内结核病的自然史：对化疗前时代文献的批判性综述
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Tuberculosis induced by droplet nuclei infection; initial homogeneous response of small mammals (rats, mice, guinea pigs, and hamsters) to human and to bovine bacilli, and the rate and pattern of tubercle development.由飞沫核感染引起的结核病；小型哺乳动物（大鼠、小鼠、豚鼠和仓鼠）对人型和牛型杆菌的初始均匀反应，以及结核结节形成的速率和模式。
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Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis.豚鼠感染结核分枝杆菌后肺部肉芽肿的免疫发病机制。
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