在通过气溶胶感染的豚鼠中，肺淋巴管是结核分枝杆菌感染的主要部位。
Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.
作者信息
Basaraba Randall J, Smith Erin E, Shanley Crystal A, Orme Ian M
机构信息
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1619, USA.
出版信息
Infect Immun. 2006 Sep;74(9):5397-401. doi: 10.1128/IAI.00332-06.
Abstract
Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.
摘要
结核分枝杆菌在经低剂量气溶胶感染的豚鼠肺部引发淋巴管炎。这一观察结果表明，肺淋巴管除了是从肺部到区域淋巴结的直接通道外，其本身也是感染部位，并且可能是潜伏感染的部位。
相似文献
1
Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.在通过气溶胶感染的豚鼠中，肺淋巴管是结核分枝杆菌感染的主要部位。
Infect Immun. 2006 Sep;74(9):5397-401. doi: 10.1128/IAI.00332-06.
2
Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge.结核分枝杆菌气溶胶感染豚鼠后，菌株依赖性中枢神经系统播散。
Tuberculosis (Edinb). 2011 Sep;91(5):386-9. doi: 10.1016/j.tube.2011.07.003. Epub 2011 Aug 9.
3
Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.感染结核分枝杆菌的豚鼠肺部病变的磁共振成像
Infect Immun. 2004 Oct;72(10):5963-71. doi: 10.1128/IAI.72.10.5963-5971.2004.
4
Experimental ocular tuberculosis in guinea pigs.豚鼠实验性眼结核
Arch Ophthalmol. 2009 Sep;127(9):1162-6. doi: 10.1001/archophthalmol.2009.220.
5
Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice.与小鼠相比，在豚鼠中加速检测对结核分枝杆菌生存至关重要的基因。
J Infect Dis. 2007 Jun 1;195(11):1634-42. doi: 10.1086/517526. Epub 2007 Apr 23.
6
Animal models of M. tuberculosis Infection.结核分枝杆菌感染的动物模型。
Curr Protoc Microbiol. 2007 Nov;Chapter 10:Unit 10A.5. doi: 10.1002/9780471729259.mc10a05s7.
7
[Guinea pigs infected by bacterial dust aerosol of Bacillus tuberculosis].
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Oct;18(5):313-5, 320.
8
The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs.在感染结核分枝杆菌的豚鼠中，将牛分枝杆菌卡介苗与结核分枝杆菌72千道尔顿融合多蛋白Mtb72F共同给药，可增强牛分枝杆菌卡介苗的保护作用。
Infect Immun. 2004 Nov;72(11):6622-32. doi: 10.1128/IAI.72.11.6622-6632.2004.
9
[Bacteriological study of 51 specimens from excisions performed for pulmonary tuberculosis between 1964 and 1968].[1964年至1968年间对51份肺结核切除标本的细菌学研究]
J Med Lyon. 1970 Jan 20;51(179):433-4 passim.
10
Protective efficacy of recombinant (Ag85A) BCG Tokyo with Ag85A peptide boosting against Mycobacterium tuberculosis-infected guinea pigs in comparison with that of DNA vaccine encoding Ag85A.与编码Ag85A的DNA疫苗相比，重组（Ag85A）卡介苗东京株联合Ag85A肽加强免疫对结核分枝杆菌感染豚鼠的保护效果。
Tuberculosis (Edinb). 2007 Mar;87(2):94-101. doi: 10.1016/j.tube.2006.05.001. Epub 2006 Jun 30.
引用本文的文献
1
Tertiary Lymphoid Structures in Tuberculosis: Persistence, Protection, and Pathology.结核病中的三级淋巴结构：持续存在、保护作用与病理学
Immunol Rev. 2025 Aug;333(1):e70055. doi: 10.1111/imr.70055.
2
Distinguishing multiple roles of T cell and macrophage involvement in determining lymph node fates during Mycobacterium tuberculosis infection.区分T细胞和巨噬细胞在结核分枝杆菌感染期间决定淋巴结命运中的多重作用。
PLoS Comput Biol. 2025 May 7;21(5):e1013033. doi: 10.1371/journal.pcbi.1013033. eCollection 2025 May.
3
Heterogeneity in immune cell composition is associated with replication at the granuloma level.免疫细胞组成的异质性与肉芽肿水平的复制有关。
Front Immunol. 2024 Aug 26;15:1427472. doi: 10.3389/fimmu.2024.1427472. eCollection 2024.
4
Comparative pathology of experimental pulmonary tuberculosis in animal models.动物模型中实验性肺结核的比较病理学
Front Vet Sci. 2023 Oct 12;10:1264833. doi: 10.3389/fvets.2023.1264833. eCollection 2023.
5
Characterisation and development of histopathological lesions in a guinea pig model of infection.感染豚鼠模型中组织病理学损伤的特征描述与发展
Front Vet Sci. 2023 Sep 22;10:1264200. doi: 10.3389/fvets.2023.1264200. eCollection 2023.
6
Imaging peripheral lymphatic dysfunction in chronic conditions.慢性疾病中外周淋巴功能障碍的成像
Front Physiol. 2023 Mar 15;14:1132097. doi: 10.3389/fphys.2023.1132097. eCollection 2023.
7
The lymphatic vasculature in lung function and respiratory disease.肺功能与呼吸系统疾病中的淋巴脉管系统
Front Med (Lausanne). 2023 Mar 14;10:1118583. doi: 10.3389/fmed.2023.1118583. eCollection 2023.
8
Lymphatic Dissemination and Axillary Web Syndrome in Primary Cutaneous Tuberculosis Secondary to Needlestick Injury.针刺伤继发原发性皮肤结核中的淋巴播散及腋网综合征
Open Forum Infect Dis. 2021 Mar 30;8(7):ofab160. doi: 10.1093/ofid/ofab160. eCollection 2021 Jul.
9
Neutrophils in Tuberculosis: Cell Biology, Cellular Networking and Multitasking in Host Defense.结核病中的中性粒细胞：宿主防御中的细胞生物学、细胞网络和多任务处理。
Int J Mol Sci. 2021 Apr 30;22(9):4801. doi: 10.3390/ijms22094801.
10
Lymph nodes-The neglected battlefield in tuberculosis.淋巴结——结核病被忽视的战场。
PLoS Pathog. 2020 Aug 13;16(8):e1008632. doi: 10.1371/journal.ppat.1008632. eCollection 2020 Aug.
本文引用的文献
1
Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis.在豚鼠结核病模型中，淋巴结炎是疾病的主要组成部分。
Tuberculosis (Edinb). 2006 Sep;86(5):386-94. doi: 10.1016/j.tube.2005.11.003. Epub 2006 Feb 10.
2
Lung remodeling in pulmonary tuberculosis.肺结核中的肺重塑
J Infect Dis. 2005 Oct 1;192(7):1201-9. doi: 10.1086/444545. Epub 2005 Aug 29.
3
In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection.体内清除CD11c+细胞会延迟CD4+ T细胞对结核分枝杆菌的反应，并加重感染结果。
J Immunol. 2005 Sep 1;175(5):3268-72. doi: 10.4049/jimmunol.175.5.3268.
4
Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.卡介苗皮内接种后，中性粒细胞通过淋巴管迅速迁移，并将活的杆菌输送至引流淋巴结。
Blood. 2005 Sep 1;106(5):1843-50. doi: 10.1182/blood-2005-03-1281. Epub 2005 May 10.
5
Current concepts of childhood tuberculosis.儿童结核病的当前概念。
Semin Pediatr Infect Dis. 2005 Apr;16(2):93-104. doi: 10.1053/j.spid.2005.01.001.
6
Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.感染结核分枝杆菌的豚鼠肺部病变的磁共振成像
Infect Immun. 2004 Oct;72(10):5963-71. doi: 10.1128/IAI.72.10.5963-5971.2004.
7
The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era.儿童胸内结核病的自然史：对化疗前时代文献的批判性综述
Int J Tuberc Lung Dis. 2004 Apr;8(4):392-402.
8
Tuberculosis induced by droplet nuclei infection; initial homogeneous response of small mammals (rats, mice, guinea pigs, and hamsters) to human and to bovine bacilli, and the rate and pattern of tubercle development.由飞沫核感染引起的结核病；小型哺乳动物（大鼠、小鼠、豚鼠和仓鼠）对人型和牛型杆菌的初始均匀反应，以及结核结节形成的速率和模式。
J Exp Med. 1953 Jan;97(1):61-8. doi: 10.1084/jem.97.1.61.
9
Pulmonary necrosis resulting from DNA vaccination against tuberculosis.抗结核DNA疫苗接种导致的肺坏死。
Infect Immun. 2003 Apr;71(4):2192-8. doi: 10.1128/IAI.71.4.2192-2198.2003.
10
Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis.豚鼠感染结核分枝杆菌后肺部肉芽肿的免疫发病机制。
Infect Immun. 2003 Feb;71(2):864-71. doi: 10.1128/IAI.71.2.864-871.2003.
Zotero 插件