Li Hongming, Wang Yong-Qiang, Deng Li
Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA.
Org Lett. 2006 Aug 31;8(18):4063-5. doi: 10.1021/ol061552a.
In this communication, we report an efficient asymmetric Friedel-Crafts reaction that, unprecedently, is applicable to a wide range of both indoles and carbonyls. The use of a readily accessible catalyst in combination with a high enantioselectivity that is insensitive to reaction concentration, temperature, air, and moisture should allow this reaction to provide useful enantioselective access to new chiral indole derivatives. [reaction: see text]
在本通讯中，我们报道了一种高效的不对称傅克反应，该反应前所未有的适用于多种吲哚和羰基化合物。使用易于获得的催化剂，结合对反应浓度、温度、空气和水分不敏感的高对映选择性，应能使该反应为新型手性吲哚衍生物提供有用的对映选择性合成途径。[反应：见正文]
