Maki Brooks E, Scheidt Karl A
Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
Org Lett. 2009 Apr 2;11(7):1651-4. doi: 10.1021/ol900306v.
Indoles and alcohols can be coupled in a dehydrogenative process catalyzed by tetrapropylammonium perruthenate. This efficient approach to indolylamides proceeds in a single flask under mild conditions. By employing substituted indoles and alkyl, branched, or benzylic alcohols, a variety of indolylamides can be formed. Aryl indolylamides can be functionalized through an additional dehydrogenative coupling to furnish elaborated polycyclic heterocycles similar to biologically active structures previously reported.
吲哚和醇类可以在过钌酸四丙铵催化的脱氢过程中偶联。这种制备吲哚酰胺的有效方法在温和条件下于单口烧瓶中进行。通过使用取代吲哚和烷基、支链或苄醇，可以形成多种吲哚酰胺。芳基吲哚酰胺可以通过额外的脱氢偶联进行官能化，以提供类似于先前报道的生物活性结构的复杂多环杂环化合物。
