Bashandy Hany G, Javillo Jason S, Gambert Steven R
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21215, USA.
South Med J. 2006 Aug;99(8):870-2. doi: 10.1097/01.smj.0000229871.68911.67.
Scleroderma renal crisis (SRC) has classically been defined as a new onset of accelerated arterial hypertension associated with a rapid increase in serum creatinine concentration and/or microangiopathic hemolytic anemia. SRC occurs in approximately 20% of patients with systemic sclerosis who have diffuse cutaneous manifestations. In addition, 10% of reported cases of SRC with diffuse cutaneous involvement have normal blood pressures; in the majority of these cases, SRC occurs after treatment with corticosteroids. We describe a patient who presented with an early onset SRC in the setting of diffuse cutaneous systemic sclerosis in evolution without prior accelerated arterial hypertension or corticosteroid use.
硬皮病肾危象（SRC）传统上被定义为新发的加速性动脉高血压，伴有血清肌酐浓度迅速升高和/或微血管病性溶血性贫血。SRC发生于约20%有弥漫性皮肤表现的系统性硬化症患者中。此外，10%报告的弥漫性皮肤受累的SRC病例血压正常；在这些病例中的大多数，SRC发生于使用皮质类固醇治疗后。我们描述了一名在弥漫性皮肤系统性硬化症进展过程中出现早期SRC的患者，该患者既往无加速性动脉高血压或未使用过皮质类固醇。
