Schwartz I S, Strauchen J A
Department of Pathology, Mount Sinai School of Medicine, City University of New York, New York.
Am J Clin Pathol. 1990 Jun;93(6):725-30. doi: 10.1093/ajcp/93.6.725.
Eight cases are reported of an unusual breast lesion consisting of dense intralobular, perilobular, and perivascular lymphocytic infiltrates associated with lobular atrophy and sclerosis. Immunologic studies on paraffin-embedded tissue (seven cases) and frozen tissue (two cases) demonstrated a predominance of B-cells and expression of HLA-DR antigen in involved lobular epithelium. The immunologic features of this lesion are reminiscent of lymphoepithelial lesions of salivary glands and other sites. A possible autoimmune pathogenesis is suggested.
报告了8例不寻常的乳腺病变，其特征为小叶内、小叶周围和血管周围有密集的淋巴细胞浸润，并伴有小叶萎缩和硬化。对石蜡包埋组织（7例）和冷冻组织（2例）进行的免疫研究显示，B细胞占优势，且受累小叶上皮中存在HLA-DR抗原表达。该病变的免疫特征使人联想到唾液腺和其他部位的淋巴上皮病变。提示可能存在自身免疫性发病机制。
