Riddoch D, Morgan-Hughes J A
J Neurol Sci. 1975 Sep;26(1):71-80. doi: 10.1016/0022-510x(75)90115-x.
The effects of long-term corticosteroid treatment have been assessed in 20 patients with polymyositis. Cases were only accepted if a muscle biopsy showed the characteristic features of inflammation and muscle fibre degeneration. If the muscle disorder was only a minor feature of generalised collagen disease or there was evidence of coexisting neuropathy, the patients were excluded. Over a mean follow-up period of 5 years, 8 patients died and only 4 improved. These results have been compared with those in other series. An attempt has been made to correlate muscle biopsy findings with prognosis, and the reasons for the poor outcome are discussed.
对20例多发性肌炎患者进行了长期皮质类固醇治疗效果的评估。仅当肌肉活检显示出炎症和肌纤维变性的特征性表现时，病例才被纳入。如果肌肉疾病只是全身性胶原病的一个次要特征，或者有并存神经病变的证据，则将患者排除。在平均5年的随访期内，8例患者死亡，仅4例病情有所改善。已将这些结果与其他系列研究的结果进行了比较。已尝试将肌肉活检结果与预后相关联，并对预后不良的原因进行了讨论。
