Miyazaki Masaya, Maeda Hideaki
Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tosu, Saga 841-0052, Japan.
Trends Biotechnol. 2006 Oct;24(10):463-70. doi: 10.1016/j.tibtech.2006.08.002. Epub 2006 Aug 28.
Microreaction technology is an interdisciplinary field combining science and engineering. It has attracted the attention of researchers from different fields for the past few years, resulting in the development of several microreactors. Enzymes are one of the catalysts used in microreactors: they are useful for substance production in an environmentally friendly way and have high potential for analytical applications. However, few enzymatic processes have been commercialized because of problems with stability and the cost and efficiency of the reactions. Thus, there have been demands for innovation in process engineering, particularly for enzymatic reactions, and microreaction devices can serve as efficient tools for the development of enzyme processes. In this review, we summarize the recent advances of enzyme-immobilized microchannel reactors; fundamental techniques for micro enzyme-reactor design and important applications of this multidisciplinary technology in chemical processing are also included in our topics.
微反应技术是一个融合科学与工程的跨学科领域。在过去几年里，它吸引了来自不同领域的研究人员的关注，催生了多种微反应器的发展。酶是微反应器中使用的催化剂之一：它们以环境友好的方式用于物质生产，在分析应用方面具有很大潜力。然而，由于稳定性以及反应成本和效率方面的问题，很少有酶促过程实现商业化。因此，人们对过程工程创新有需求，特别是针对酶促反应，而微反应装置可作为开发酶促过程的有效工具。在这篇综述中，我们总结了固定化酶微通道反应器的最新进展；微酶反应器设计的基础技术以及这项多学科技术在化学加工中的重要应用也包含在我们的主题中。
