Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 807-1 Shuku, Tosu, Saga 841-0052, Japan.
Molecules. 2011 Jul 19;16(7):6041-59. doi: 10.3390/molecules16076041.
Microreaction technology, which is an interdisciplinary science and engineering area, has been the focus of different fields of research in the past few years. Several microreactors have been developed. Enzymes are a type of catalyst, which are useful in the production of substance in an environmentally friendly way, and they also have high potential for analytical applications. However, not many enzymatic processes have been commercialized, because of problems in stability of the enzymes, cost, and efficiency of the reactions. Thus, there have been demands for innovation in process engineering, particularly for enzymatic reactions, and microreaction devices represent important tools for the development of enzyme processes. In this review, we summarize the recent advances of microchannel reaction technologies especially for enzyme immobilized microreactors. We discuss the manufacturing process of microreaction devices and the advantages of microreactors compared to conventional reaction devices. Fundamental techniques for enzyme immobilized microreactors and important applications of this multidisciplinary technology are also included in our topics.
微反应技术是一门跨学科的科学和工程领域，在过去几年中一直是不同研究领域的焦点。已经开发了几种微反应器。酶是一种催化剂，它们在以环保的方式生产物质方面非常有用，并且在分析应用方面也有很高的潜力。然而，由于酶的稳定性、成本和反应效率等问题，并没有很多酶促反应实现商业化。因此，人们对工艺工程，特别是酶反应的创新提出了要求，微反应装置是酶反应发展的重要工具。在这篇综述中，我们总结了微通道反应技术，特别是固定化酶微反应器的最新进展。我们讨论了微反应装置的制造工艺以及与传统反应装置相比微反应器的优势。我们还包括了固定化酶微反应器的基础技术和这项多学科技术的重要应用。
