Marcinek Andrzej, Katarzynska Joanna, Sieron Leslaw, Skokowski Robert, Zielinski Jacek, Gebicki Jerzy
Institute of Applied Radiation Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.
Angionica Ltd., 90-924 Lodz, Poland.
Biology (Basel). 2023 Feb 28;12(3):385. doi: 10.3390/biology12030385.
Flow Mediated Skin Fluorescence (FMSF) is a new non-invasive method for assessing vascular circulation and/or metabolic regulation. It enables assessment of both vasoconstriction and vasodilation. The method measures stimulation of the circulation in response to post-occlusive reactive hyperemia (PORH). It analyzes the dynamical changes in the emission of NADH fluorescence from skin tissue, providing the information on mitochondrial metabolic status and intracellular oxygen delivery through the circulatory system. Assessment of the vascular state using the FMSF technique is based on three parameters: reactive hyperemia response (RHR), hypoxia sensitivity (HS), and normoxia oscillatory index (NOI). The RHR and HS parameters determine the risk of vascular circulatory disorders and are the main diagnostic parameters. The NOI parameter is an auxiliary parameter for evaluating the state of microcirculation under stress of various origins (e.g., emotional stress, physical exhaustion, or post-infection stress). The clinical data show that the risk of vascular complications is limited among people whose RHR, log(HS), and NOI parameters are not significantly below the mean values determined by the FMSF technique, especially if they simultaneously meet the conditions RHR > 30% and log(HS) > 1.5 (HS > 30), and NOI > 60%.
血流介导的皮肤荧光（FMSF）是一种用于评估血管循环和/或代谢调节的新型非侵入性方法。它能够评估血管收缩和血管舒张。该方法测量对闭塞后反应性充血（PORH）的循环刺激。它分析皮肤组织中NADH荧光发射的动态变化，提供有关线粒体代谢状态和通过循环系统的细胞内氧输送的信息。使用FMSF技术评估血管状态基于三个参数：反应性充血反应（RHR）、缺氧敏感性（HS）和常氧振荡指数（NOI）。RHR和HS参数决定血管循环障碍的风险，是主要的诊断参数。NOI参数是评估各种原因（如情绪压力、身体疲劳或感染后压力）应激下微循环状态的辅助参数。临床数据表明，RHR、log(HS)和NOI参数未显著低于FMSF技术确定的平均值的人群中，血管并发症的风险有限，特别是当他们同时满足RHR > 30%、log(HS) > 1.5（HS > 30）和NOI > 60%的条件时。
