Menczer J, Leventon-Kriss S, Modan M, Oelsner G, Gerichter C B
J Natl Cancer Inst. 1975 Jul;55(1):3-6. doi: 10.1093/jnci/55.1.3.
Herpes simplex virus (HSV) antibody titers were examined in sera from 39 Jewish women with squamous cell carcinoma of the uterine cervix (CaCx) and in sera from controls matched by age and country of origin. Highly significant differences were found between the cases and controls for both HSV type 1 (HSV-1) and HSV type 2 (HSV-2). Compared to findings in other demographic areas, the geometric mean titer (GMT) of HSV-1 among the CaCx cases were considerably higher, whereas the GMT for HSV-2 was in the same range. The percentage of HSV-2-positive patients, as defined by the HSV-2/HSV-1 antibody titer ratio was low compared to that found in other demographic areas; this was presumably due to the high incidence of HSV-1 infection in the population. The HSV-1 and HSV-2 infection rate in the Israeli Jewish female population was estimated by antibody titers for 94 healthy subjects. The GMT of HSV-1 was considerably higher, whereas the GMT of HSV-2 was lower, than those reported elsewhere. The association found previously between HSV-2 and CaCx remained true for Jewish women. Their low incidence of CaCx, which did not seem to result from lower susceptibility, might be explained by the low incidence of HSV-2 infection.
对39名患有子宫颈鳞状细胞癌（CaCx）的犹太女性的血清以及年龄和原籍国相匹配的对照组血清进行了单纯疱疹病毒（HSV）抗体滴度检测。在1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）方面，病例组和对照组之间均发现了高度显著差异。与其他人口统计学区域的研究结果相比，CaCx病例组中HSV-1的几何平均滴度（GMT）明显更高，而HSV-2的GMT处于相同范围。根据HSV-2/HSV-1抗体滴度比值定义的HSV-2阳性患者百分比与其他人口统计学区域相比很低；这可能是由于该人群中HSV-1感染的高发病率。通过对94名健康受试者的抗体滴度估计了以色列犹太女性人群中的HSV-1和HSV-2感染率。HSV-1的GMT明显更高，而HSV-2的GMT低于其他地方报道的水平。先前发现的HSV-2与CaCx之间的关联在犹太女性中仍然成立。她们CaCx发病率低，这似乎并非由于易感性较低，可能是由HSV-2感染率低所解释。
