视网膜母细胞瘤（Rb），它不再仅仅存在于后生动物中了。（你提供的原文“Rb, whi it's not just for metazoans anymore.”似乎有误，推测正确表述可能是“Rb, which is not just for metazoans anymore.” 这里按照推测后的正确内容翻译）

Rb, whi it's not just for metazoans anymore.

作者信息

Cooper K

机构信息

Department of Molecular Biology, UMDNJ-SOM, Stratford, NJ 08084,, USA.

出版信息

Oncogene. 2006 Aug 28;25(38):5228-32. doi: 10.1038/sj.onc.1209630.

DOI:10.1038/sj.onc.1209630

PMID:16936741

Abstract

The E2F family of heterodimeric transcription factors controls the expression of genes required in G1 for cell cycle progression. The retinoblastoma (Rb) family of pocket proteins which, upon binding to E2F, inhibit this complex from initiating transcription. Upon mitogen stimulation, this repression is relieved by hyperphosphorylation of Rb by the cyclin D Cdk4/6 complex. Initiation of the cell cycle in yeast is similar. The heterodimeric transcription factor SBF controls most G1-specific transcription. Its activation is dependent upon the removal of Whi5; a functional homolog of Rb. Similar to Rb, disassociation of Whi5 from SBF is controlled by G1 cyclin/Cdk-dependent phosphorylation. Although Rb and Whi5 play similar roles in regulating G1 gene expression, they exhibit no sequence homology. This review will discuss the difference and similarities between how these proteins play similar roles in controlling G1 progression.

摘要

异二聚体转录因子E2F家族控制着细胞周期进程中G1期所需基因的表达。口袋蛋白的视网膜母细胞瘤（Rb）家族在与E2F结合后，会抑制该复合物启动转录。有丝分裂原刺激后，细胞周期蛋白D Cdk4/6复合物使Rb发生过度磷酸化，从而解除这种抑制作用。酵母细胞周期的启动也类似。异二聚体转录因子SBF控制着大多数G1期特异性转录。其激活依赖于Whi5的去除，Whi5是Rb的功能同源物。与Rb相似，Whi5与SBF的解离受G1期细胞周期蛋白/Cdk依赖性磷酸化的控制。尽管Rb和Whi5在调节G1期基因表达中发挥相似作用，但它们没有序列同源性。本综述将讨论这些蛋白质在控制G1期进程中发挥相似作用的异同。