从G0期到S期：视网膜母细胞瘤（Rb）家族成员在Rb-E2F通路中所起作用的观点。
From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway.
作者信息
Sun Ang, Bagella Luigi, Tutton Steven, Romano Gaetano, Giordano Antonio
机构信息
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg. Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA.
出版信息
J Cell Biochem. 2007 Dec 15;102(6):1400-4. doi: 10.1002/jcb.21609.
Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.
肿瘤抑制因子pRb/p105、pRb/p107和pRb2/p130基因属于视网膜母细胞瘤（Rb）基因家族。Rb基因家族成员和转录因子E2F在调节细胞周期以及由此调节细胞增殖中发挥着至关重要的作用。这篇小型综述描述了Rb家族成员和E2F调节细胞周期进程的机制。
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