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用干扰素治疗新西兰黑鼠：自身免疫性疾病进展加速。

Interferon treatment of NZB mice: accelerated progression of autoimmune disease.

作者信息

Heremans H, Billiau A, Colombatti A, Hilgers J, de Somer P

出版信息

Infect Immun. 1978 Sep;21(3):925-30. doi: 10.1128/iai.21.3.925-930.1978.

DOI:10.1128/iai.21.3.925-930.1978
PMID:213392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422085/
Abstract

The effect of long-term administration of interferon in New Zealand Black and New Zealand Black/New Zealand White F1 hybrid mice was studied. Treatment with moderate doses of interferon (10(4) units, five times weekly for 8 weeks) did not depress murine leukemia virus gp69/71 levels in serum and spleen, nor p30 levels in the spleen. Interferon given at 10(5.1) units (three times weekly for 37 weeks) caused an increased incidence of anti-erythrocyte antibodies in New Zealand Black mice. Finally, the hybrid mice given interferon at 10(6.0) units (three times weekly for 33 weeks) had increased renal immune complex deposits and increased incidences of proteinuria and anemia.

摘要

研究了长期给予干扰素对新西兰黑鼠及新西兰黑鼠/新西兰白鼠F1杂交小鼠的影响。用中等剂量的干扰素（10⁴单位，每周5次，共8周）进行治疗，并未降低血清和脾脏中鼠白血病病毒gp69/71的水平，也未降低脾脏中p30的水平。给予10⁵·¹单位的干扰素（每周3次，共37周）可使新西兰黑鼠抗红细胞抗体的发生率增加。最后，给予10⁶·⁰单位干扰素（每周3次，共33周）的杂交小鼠肾脏免疫复合物沉积增加，蛋白尿和贫血的发生率升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/900d/422085/ed9b845a9eeb/iai00201-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/900d/422085/ed9b845a9eeb/iai00201-0243-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/900d/422085/ed9b845a9eeb/iai00201-0243-a.jpg

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Interferon treatment of NZB mice: accelerated progression of autoimmune disease.用干扰素治疗新西兰黑鼠：自身免疫性疾病进展加速。
Infect Immun. 1978 Sep;21(3):925-30. doi: 10.1128/iai.21.3.925-930.1978.
2
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本文引用的文献

1
The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid.新西兰小鼠自身免疫的发病机制。II. 聚肌苷酸-聚胞苷酸对肾小球肾炎的加速作用。
Lab Invest. 1970 Dec;23(6):628-34.
2
The pathogenesis of autoimmunity in New Zealand mice, I. Induction of antinucleic acid antibodies by polyinosinic-polycytidylic acid.新西兰小鼠自身免疫的发病机制，I. 聚肌苷酸-聚胞苷酸诱导抗核酸抗体的产生
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1102-7. doi: 10.1073/pnas.63.4.1102.
3
Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice.
Cytokines and MicroRNAs as Candidate Biomarkers for Systemic Lupus Erythematosus.
细胞因子和微小RNA作为系统性红斑狼疮的候选生物标志物
Int J Mol Sci. 2015 Oct 13;16(10):24194-218. doi: 10.3390/ijms161024194.
4
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.CD180的结扎以Lyn-磷脂酰肌醇-3-激酶-BTK依赖的方式抑制B细胞中的IFN-α信号传导。
Cell Mol Immunol. 2017 Feb;14(2):192-202. doi: 10.1038/cmi.2015.61. Epub 2015 Aug 17.
5
Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling.自身免疫相关蛋白酪氨酸磷酸酶PEP对IFN-α受体信号传导起负向调节作用。
J Exp Med. 2015 Jun 29;212(7):1081-93. doi: 10.1084/jem.20142130. Epub 2015 Jun 15.
6
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J Interferon Cytokine Res. 2013 Nov;33(11):646-59. doi: 10.1089/jir.2012.0171. Epub 2013 Jun 18.
7
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8
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9
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10
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HSS J. 2009 Sep;5(2):169-77. doi: 10.1007/s11420-009-9123-x. Epub 2009 Jul 16.
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J Exp Med. 1971 Jan 1;133(1):113-32. doi: 10.1084/jem.133.1.113.
4
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5
Further implication of murine leukemia-like virs in the disorders of NZB mice.鼠白血病样病毒在新西兰黑小鼠疾病中的进一步影响。
J Exp Med. 1969 May 1;129(5):1045-62. doi: 10.1084/jem.129.5.1045.
6
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7
The pathogenesis of autoimmunity in New Zealand black mice.新西兰黑鼠自身免疫的发病机制。
Curr Top Microbiol Immunol. 1974;64(0):79-103. doi: 10.1007/978-3-642-65848-8_3.
8
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9
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Immunology. 1975 Oct;29(4):745-8.
10
Progressive glomerulonephritis in mice treated with interferon preparations at birth.出生时用干扰素制剂治疗的小鼠中的进行性肾小球肾炎。
Nature. 1976 Sep 30;263(5576):420-2. doi: 10.1038/263420a0.