Salit Marc
Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Methods Enzymol. 2006;411:63-78. doi: 10.1016/S0076-6879(06)11005-8.
The use of standards in gene expression measurements with DNA microarrays is ubiquitous--they just are not yet the kind of standards that have yielded microarray gene expression profiles that can be readily compared across different studies and different laboratories. They also are not yet enabling microarray measurements of the known, verifiable quality needed so they can be used with confidence in genomic medicine in regulated environments.
在使用DNA微阵列进行基因表达测量时,标准的应用十分普遍——只是目前这些标准还无法产生那种能够在不同研究和不同实验室之间轻松比较的微阵列基因表达谱。它们也尚未具备使微阵列测量达到所需的已知、可验证质量的能力,因此无法在受监管环境下的基因组医学中放心使用。