Navon-Venezia Shiri, Chmelnitsky Inna, Leavitt Azita, Schwaber Mitchell J, Schwartz David, Carmeli Yehuda
Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel.
Antimicrob Agents Chemother. 2006 Sep;50(9):3098-101. doi: 10.1128/AAC.00438-06.
Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.
大肠埃希菌对碳青霉烯类耐药较为罕见。我们报告了从特拉维夫医疗中心住院的4名患者中培养出的4株基因不相关的耐碳青霉烯类大肠埃希菌分离株。聚合酶链反应（PCR）、测序及Southern印迹分析确定，这4株菌株中使亚胺培南水解的酶均为KPC-2，该酶位于不同质粒上，可能有共同起源。这是首次在大肠埃希菌中发现KPC-2，也是该酶起源于美国境外的首次报道。
