胆固醇作为毒素的作用靶点。
Cholesterol as a target for toxins.
作者信息
de Kruijff B
机构信息
Centre for Biomembranes and Lipid Enzymology, University of Utrecht, NL.
出版信息
Biosci Rep. 1990 Apr;10(2):127-30. doi: 10.1007/BF01116571.
PMID:1694094
Abstract
A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.
摘要
提出了一种关于胆固醇促进多烯抗生素和细菌蛋白毒素形成通道的方式的机制。该模型的核心要素为：(i) 固醇的环系统与多烯或毒素分子的刚性元件之间的相互作用，以及 (ii) 胆固醇在膜内的特定取向。
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