Füst G, Kavai M, Szegedi G, Meretey K, Falus A, Lenkey A, Misz M
J Immunol Methods. 1980;38(3-4):281-9. doi: 10.1016/0022-1759(80)90276-8.
Forty serum samples of healthy blood donors and 60 sera of SLE patients were tested in parallel by 7 different assays for detecting immune complexes. Significantly higher titres and significant higher incidence of positive results were observed in the patient group than in the control group in 6 tests. No test discriminated between patients in an active stage of the disease and those whose disease was inactive. Significantly higher immune complex levels were found in lupus nephritis than in the non-nephritic patients by the complement consumption test. Significant positive correlation was obtained between the results of the macrophage aggregated IgG uptake inhibition and PEG-precipitation tests and between two tests based on the interaction of the complexes with the complement system. A characteristic 'profile' of the immune complex assay was observed in the course of the repeated testings of the same patients. The results indicate that the different methods detect different types of immune complexes present in the blood of the patients.
对40份健康献血者的血清样本和60份系统性红斑狼疮（SLE）患者的血清样本，同时采用7种不同的检测方法检测免疫复合物。在6项检测中，患者组的滴度显著更高，阳性结果的发生率也显著高于对照组。没有检测方法能够区分疾病活动期的患者和疾病非活动期的患者。通过补体消耗试验发现，狼疮性肾炎患者的免疫复合物水平显著高于非肾炎患者。巨噬细胞聚集IgG摄取抑制试验和聚乙二醇（PEG）沉淀试验的结果之间，以及基于复合物与补体系统相互作用的两项试验之间，均获得了显著的正相关。在对同一患者的重复检测过程中，观察到了免疫复合物检测的特征性“图谱”。结果表明，不同的方法检测到患者血液中存在的不同类型的免疫复合物。
