Salinas F A, Wee K H, Silver H K
Biomed Pharmacother. 1983;37(5):211-8.
The vast data pertaining to circulating immune complexes (CIC) detection and their possible clinical significance in human neoplasia have been reviewed. The clinical relevance of CIC occurrence in cancer patients' sera provide important non-diagnostic information on staging, evaluation of prognosis, detection of early recurrence, and quantitation of tumor response to treatment. A variable prevalence of CIC in cancer patients is now well established. The several reasons which made no available test entirely satisfactory for clinical use, have been discussed indicating the importance of molecular size and composition heterogeneity of CIC detected in cancer patients. Although the evaluation of CIC by current assays represents the antithesis of pre-diagnostic patients management, there are solid reports to suggest its possible clinical application. Those studies noting the relevance of CIC fluctuation to the evaluation of prognosis, monitoring of therapy and assessment of tumor burden were best attained when an effort to quantitate residual disease was undertaken. In addition, attempts to remove CIC from cancer patients circulation by plasma exchange alone or with extracorporeal immunoadsorption have resulted in a better understanding of a frequently observed immunomodulation. This modality provided a challenging and provocative new approach to cancer therapy which deserved prompt corroboration.
本文综述了与循环免疫复合物（CIC）检测及其在人类肿瘤中可能的临床意义相关的大量数据。癌症患者血清中CIC的出现具有临床相关性，可为分期、预后评估、早期复发检测以及肿瘤对治疗反应的定量提供重要的非诊断性信息。目前已明确癌症患者中CIC的患病率各不相同。文中讨论了导致现有检测方法均不能完全满足临床应用的几个原因，指出了癌症患者中检测到的CIC分子大小和组成异质性的重要性。尽管目前的检测方法对CIC的评估与诊断前患者管理背道而驰，但有可靠报告表明其可能具有临床应用价值。当努力对残留疾病进行定量时，那些注意到CIC波动与预后评估、治疗监测和肿瘤负荷评估相关性的研究取得了最佳效果。此外，单独通过血浆置换或联合体外免疫吸附从癌症患者循环中去除CIC的尝试，使人们对经常观察到的免疫调节有了更好的理解。这种方法为癌症治疗提供了一种具有挑战性和启发性的新途径，值得迅速加以证实。
