Brown S E, Howard C R, Steward M W, Ajdukiewicz A B, Whittle H C
Clin Exp Immunol. 1984 Feb;55(2):355-9.
IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin solid phase assays in both HBsAg+ and HBsAg- groups of patients with primary hepatocellular carcinoma (HCC). No differences were observed between the two patient groups either in the levels of antigen non-specific and HBsAg specific complexes or in the immunoglobulin isotype in the complexes. The results show that HBsAg can occur in an IC form in the sera of patients classified as HBsAg- by sensitive commercial assays and provides evidence of a further association of hepatitis B virus (HBV) and HCC in antigen negative patients. Furthermore, the HBsAg IC in HCC patients differ from those in other HBV infected subjects in that they are preferentially detected by the Clq assay.
采用Clq和胶固素固相分析法，在原发性肝细胞癌（HCC）患者的HBsAg阳性和HBsAg阴性两组中检测到了含有IgG、IgM和乙肝表面抗原（HBsAg）的免疫复合物（IC）。在两组患者之间，无论是抗原非特异性和HBsAg特异性复合物的水平，还是复合物中的免疫球蛋白同种型，均未观察到差异。结果表明，在通过灵敏的商业检测分类为HBsAg阴性的患者血清中，HBsAg可以以IC形式出现，并为乙肝病毒（HBV）与抗原阴性患者的HCC之间存在进一步关联提供了证据。此外，HCC患者中的HBsAg IC与其他HBV感染受试者中的不同，因为它们优先通过Clq分析法检测到。
