Gonzalo-Ruiz A, Leichnetz G R, Hardy S G
Department of Anatomy, University College, Soria, Spain.
J Comp Neurol. 1990 Jun 15;296(3):427-36. doi: 10.1002/cne.902960308.
The mesencephalic projections of the medial cerebellar nucleus (MCN) were studied in the rat by using the method of anterograde transport of wheat germ agglutinin/horseradish peroxidase to establish connections of the nucleus with oculomotor-related nuclei as a basis for its proposed role in eye movement. The principal targets of projections were the supraoculomotor ventral periaqueductal gray (PAG) and lateral PAG, and paraoculomotor cell groups (nucleus of Darkschewitsch and medial accessory nucleus of Bechterew). Lesser projections were observed to the intermediate layer of the superior colliculus, nucleus of the posterior commissure, and prerubral field. Following transcannular HRP gel implants into the oculomotor complex that included adjacent paraoculomotor nuclei, the largest number of retrogradely labeled cells was found in the caudal MCN. The findings suggest that the caudal MCN in the rat, like the primate fastigial nucleus, is involved in the control of eye movement.
采用小麦胚凝集素/辣根过氧化物酶顺行运输法，在大鼠中研究了内侧小脑核（MCN）的中脑投射，以建立该核与动眼相关核的联系，作为其在眼球运动中假定作用的基础。投射的主要靶点是动眼上腹中脑导水管周围灰质（PAG）和外侧PAG，以及动眼旁细胞群（达克谢维奇核和别赫捷列夫内侧副核）。观察到向中脑上丘中间层、后连合核和红核前区的投射较少。将HRP凝胶经套管植入包括相邻动眼旁核的动眼复合体后，在尾侧MCN中发现逆行标记细胞数量最多。研究结果表明，大鼠的尾侧MCN与灵长类动物的顶核一样，参与眼球运动的控制。
