Ikeda Y, Noda H, Sugita S
Visual Science Department, School of Optometry, Indiana University, Bloomington 47405.
J Comp Neurol. 1989 Jun 15;284(3):463-88. doi: 10.1002/cne.902840311.
Anatomical connections of the caudal portion of the fastigial nucleus (FN) with the inferior olive (IO) were studied in macaque monkeys with wheat-germ-agglutinin-conjugated horseradish peroxidase (WGA/HRP) and HRP. When injected HRP was confined to a caudal portion of the FN, retrogradely labeled Purkinje cells (P cells) appeared in the oculomotor vermis. We defined the area that receives the projection from vermal lobule VII as the fastigial oculomotor region. The same HRP injection resulted in retrograde labeling of IO neurons in an area of group b (of Bowman and Sladek: J. Comp. Neurol. 152:299-316, '73) of the contralateral medial accessory olive (MAO). This area was designated as the Z-portion because in the coronal section it appears like the letter "Z." Retrogradely labeled IO neurons were also found in the Z-portion when HRP was injected into the oculomotor vermis, indicating that neurons in this portion project to both the fastigial and vermal oculomotor regions. Anterogradely labeled axons from the contralateral fastigial oculomotor region also terminated in the Z-portion. When the effective site included a region anterior to the fastigial oculomotor region, labeled P cells appeared in lobule V and labeled IO neurons appeared in group a. Labeled terminals of fastigial fibers were also found in group a. When the effective site included a region ventral to the oculomotor region, labeled P cells appeared in vermal lobules VIII and IX and labeled IO neurons appeared in caudal parts of a and b, in addition to group c. HRP injection into the posterior interposed nucleus (PIN) resulted in labeling of P cells in the paravermal zone and of IO neurons in the rostral two-thirds of the MAO and the dorsal accessory olive (DAO). The location of the labeled terminals coincided with the region where the densest labeling of IO neurons was found. Thus, the olivary projections to both the cerebellar cortex and deep cerebellar nuclei and the nucleoolivary projection exhibited a closely related topographical organization.
利用小麦胚凝集素结合辣根过氧化物酶（WGA/HRP）和HRP，在猕猴中研究了顶核尾部（FN）与下橄榄核（IO）的解剖学连接。当将HRP注射局限于FN的尾部时，在动眼神经小脑蚓部出现逆行标记的浦肯野细胞（P细胞）。我们将接受来自小脑蚓小叶VII投射的区域定义为顶核动眼神经区。相同的HRP注射导致对侧内侧副橄榄核（MAO）的b组区域（Bowman和Sladek：《比较神经学杂志》152:299 - 316，'73）中的IO神经元逆行标记。该区域被指定为Z区，因为在冠状切片中它看起来像字母“Z”。当将HRP注入动眼神经小脑蚓部时，在Z区也发现了逆行标记的IO神经元，表明该区域的神经元投射到顶核和小脑蚓动眼神经区。来自对侧顶核动眼神经区的顺行标记轴突也终止于Z区。当有效部位包括顶核动眼神经区前方的区域时，在小叶V中出现标记的P细胞，在a组中出现标记的IO神经元。在a组中也发现了顶核纤维的标记终末。当有效部位包括动眼神经区腹侧的区域时，除了c组外，在小脑蚓小叶VIII和IX中出现标记的P细胞，在a和b的尾部以及c组中出现标记的IO神经元。将HRP注入后间位核（PIN）导致在旁小脑区的P细胞以及MAO和背侧副橄榄核（DAO）的前三分之二的IO神经元标记。标记终末的位置与发现IO神经元最密集标记的区域一致。因此，橄榄核向小脑皮质和小脑深部核团的投射以及核橄榄投射呈现出密切相关的拓扑组织。
