Davies Julian, Spiegelman George B, Yim Grace
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 01Z3, Canada.
Curr Opin Microbiol. 2006 Oct;9(5):445-53. doi: 10.1016/j.mib.2006.08.006. Epub 2006 Aug 30.
Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription analyses that these activities have been studied in detail at the level of cell metabolism. It has been shown that all antibiotics, regardless of their receptors and mode of action, exhibit the phenomenon of hormesis and provoke considerable transcription activation at low concentrations. These analyses should be of value in providing information on antibiotic side-effects, in bioactive natural product discovery and antibiotic mode-of-action studies.
尽管长期以来人们都知道抗生素在低浓度下对细菌细胞有多种作用，但直到基因组转录分析出现，这些活性才在细胞代谢水平上得到详细研究。研究表明，所有抗生素，无论其受体和作用方式如何，都表现出兴奋效应现象，并且在低浓度下会引发相当程度的转录激活。这些分析对于提供抗生素副作用信息、生物活性天然产物发现以及抗生素作用方式研究应具有重要价值。
