Zhang Yi-fei, Yang Yi-sheng, Hong Jie, Gu Wei-qiong, Shen Chun-fang, Xu Min, Du Peng-fei, Li Xiao-ying, Ning Guang
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, 200025, Shanghai, P R China.
Endocrine. 2006 Jun;29(3):419-23. doi: 10.1385/ENDO:29:3:419.
Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1 cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndrome (PCOS) patients. In the present study we evaluated the association of serum IL-18 levels with insulin resistance in PCOS women. Forty-two PCOS women and 38 control subjects were enrolled in this study and matched with respect to age and body mass index (BMI). Serum IL-18 levels and hormones were measured for all subjects. Furthermore, euglycemic hyperinsulinemic clamp test was performed in selected 30 PCOS women and 11 control subjects. Serum IL-18 levels were elevated in PCOS women compared with the control (p = 0.033). IL-18 levels were positively correlated with homeostasis model assessment index (HOMA) beta index, which assesses beta cell function (p = 0.035), but were inversely correlated with clamp indices, which best represent insulin resistance status: M, Clamp ISI*100, and MCRg values (p = 0.006, 0.010, and 0.009 respectively). No correlation was found between IL-18 and age, BMI, waist-to-hip ratio (WHR), lipid profile, dehydroepiandrosterone-sulfate (DHEAS), sex hormone- binding globulin (SHBG), or fasting insulin levels. In conclusion, in the present study, serum IL-18 levels were significantly increased in PCOS women and firmly associated with insulin resistance displayed by euglycemic hyperinsulinemic clamp test. It indicates that IL-18 may be a contributing factor linking inflammation and insulin resistance in PCOS women.
促炎因子的过度产生与肥胖和糖尿病有关。白细胞介素（IL）-18作为IL-1细胞因子家族的一员，在肥胖患者、糖尿病患者甚至多囊卵巢综合征（PCOS）患者中均有升高。在本研究中，我们评估了PCOS女性血清IL-18水平与胰岛素抵抗之间的关联。本研究纳入了42例PCOS女性和38例对照受试者，并在年龄和体重指数（BMI）方面进行了匹配。对所有受试者测量血清IL-18水平和激素。此外，对30例选定的PCOS女性和11例对照受试者进行了正常血糖高胰岛素钳夹试验。与对照组相比，PCOS女性的血清IL-18水平升高（p = 0.033）。IL-18水平与评估β细胞功能的稳态模型评估指数（HOMA）β指数呈正相关（p = 0.035），但与最能代表胰岛素抵抗状态的钳夹指数呈负相关：M、钳夹ISI*100和MCRg值（分别为p = 0.006、0.010和0.009）。未发现IL-18与年龄、BMI、腰臀比（WHR）、血脂谱、硫酸脱氢表雄酮（DHEAS）、性激素结合球蛋白（SHBG）或空腹胰岛素水平之间存在相关性。总之，在本研究中，PCOS女性的血清IL-18水平显著升高，且与正常血糖高胰岛素钳夹试验显示的胰岛素抵抗密切相关。这表明IL-18可能是PCOS女性中连接炎症和胰岛素抵抗的一个促成因素。
