Shaikh Saame Raza, Edidin Michael A
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Baltimore, MD 21218, USA.
Chem Phys Lipids. 2006 Oct;144(1):1-3. doi: 10.1016/j.chemphyslip.2006.06.017. Epub 2006 Jul 21.
A new definition for lipid rafts was coined at the Keystone Symposium of Lipid Rafts and Cell Function based on recent advances in the field. The revised definition lumps all membrane heterogeneities that are not rafts into a single class of "non-raft". In this commentary, we suggest that "non-raft" domains encompass a variety of membrane heterogeneities and are quite diverse in composition and origin. A good starting point for the study of this diversity would be phospholipids with unsaturated acyl chains, which display little affinity for cholesterol; these lipids are abundant in membranes such as the endoplasmic reticulum and that may form their own macro- or microdomains.
基于该领域的最新进展，在脂质筏与细胞功能基石研讨会上提出了脂质筏的新定义。修订后的定义将所有非筏状的膜异质性归为一类“非筏”。在本评论中，我们认为“非筏”结构域包含多种膜异质性，且在组成和起源上差异很大。研究这种多样性的一个良好起点是具有不饱和酰基链的磷脂，它们对胆固醇的亲和力很低；这些脂质在内质网等膜中含量丰富，可能形成自身的大结构域或微结构域。
