Merendino R A, Arena A, Liberto M C, Mesiti M, Chillemi S, Iannello D, Bonina L
Institute of Medical Microbiology, University of Messina, Italy.
J Chemother. 1990 Apr;2(2):116-22. doi: 10.1080/1120009x.1990.11738994.
Macrophages derived from in vitro cultured monocytes were infected with herpes simplex virus type 2. A marked impairment in the intrinsic antiviral activity was found in macrophages obtained from patients with breast cancer or melanoma. Moreover, the antiviral activity of macrophages from healthy donors, differentiated in serum from patients with neoplasia, was also impaired. The aim of this work was the evaluation of alpha, beta, gamma exogenous interferon in restoring the intrinsic antiviral activity of macrophages from patients affected by breast cancer or melanoma under different conditions. Pretreatment of macrophages with alpha, beta interferons, but not gamma interferon, restored their impaired intrinsic antiviral activity.
将体外培养的单核细胞衍生的巨噬细胞用2型单纯疱疹病毒感染。在从乳腺癌或黑色素瘤患者获得的巨噬细胞中发现其内在抗病毒活性有明显损害。此外，在肿瘤患者血清中分化的健康供体巨噬细胞的抗病毒活性也受到损害。这项工作的目的是评估α、β、γ外源性干扰素在不同条件下恢复乳腺癌或黑色素瘤患者巨噬细胞内在抗病毒活性的情况。用α、β干扰素而非γ干扰素预处理巨噬细胞可恢复其受损的内在抗病毒活性。
